pI: 8.6142 |
Length (AA): 231 |
MW (Da): 26296 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
18 | 227 | 3oii (A) | 34 | 251 | 49.00 | 0 | 1 | 1.56899 | -1.11 |
20 | 227 | 5fai (A) | 38 | 243 | 60.00 | 0 | 1 | 1.69363 | -1.2 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127748)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G57000 | nucleolar essential protein-related protein |
Babesia bovis | BBOV_I002890 | suppressor Mra1 family domain containing protein |
Brugia malayi | Bm1_42740 | Probable ribosome biogenesis protein NEP1 |
Candida albicans | CaO19.8282 | conserved Nucleolar Essential Protein involved in rRNA processing |
Candida albicans | CaO19.665 | conserved Nucleolar Essential Protein involved in rRNA processing |
Caenorhabditis elegans | CELE_Y39A1A.14 | Protein Y39A1A.14 |
Cryptosporidium hominis | Chro.40319 | ribosome biogenesis protein nep1 |
Cryptosporidium parvum | cgd4_2840 | Mra1/NEP1 like protein, involved in pre-rRNA processing, adjacent genes putative paralogs |
Dictyostelium discoideum | DDB_G0272732 | hypothetical protein |
Drosophila melanogaster | Dmel_CG3527 | CG3527 gene product from transcript CG3527-RA |
Echinococcus granulosus | EgrG_000174900 | ribosomal RNA small subunit methyltransferase |
Entamoeba histolytica | EHI_044610 | ribosome biogenesis protein NEP1, putative |
Echinococcus multilocularis | EmuJ_000174900 | ribosomal RNA small subunit methyltransferase |
Giardia lamblia | GL50803_5786 | Ribosome biogenesis protein NEP1, putative |
Homo sapiens | 10436 | EMG1 N1-specific pseudouridine methyltransferase |
Leishmania braziliensis | LbrM.16.1450 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_161470.1 | EMG1/NEP1 methyltransferase, putative |
Leishmania infantum | LinJ.16.1470 | hypothetical protein, conserved |
Leishmania major | LmjF.16.1390 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.16.1390 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_03665 | C2f protein |
Mus musculus | ENSMUSG00000004268 | EMG1 nucleolar protein homolog (S. cerevisiae) |
Neospora caninum | NCLIV_057180 | Suppressor Mra1 superfamily, related |
Oryza sativa | 4329057 | Os02g0290400 |
Plasmodium berghei | PBANKA_0709300 | ribosomal RNA small subunit methyltransferase NEP1, putative |
Plasmodium falciparum | PF3D7_0821500 | ribosomal RNA small subunit methyltransferase NEP1, putative |
Plasmodium knowlesi | PKNH_1315500 | ribosomal RNA small subunit methyltransferase NEP1, putative |
Plasmodium vivax | PVX_089290 | ribosomal RNA small subunit methyltransferase NEP1, putative |
Saccharomyces cerevisiae | YLR186W | Emg1p |
Schistosoma japonicum | Sjp_0066750 | Probable ribosome biogenesis protein NEP1, putative |
Schistosoma mansoni | Smp_002010 | nep1 |
Schmidtea mediterranea | mk4.004989.00 | Putative nep1 |
Schmidtea mediterranea | mk4.003823.06 | Putative nep1 |
Trypanosoma brucei gambiense | Tbg972.8.4840 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.8.5040 | EMG1/NEP1 methyltransferase, putative |
Trypanosoma congolense | TcIL3000_8_4790 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.447705.9 | EMG1/NEP1 methyltransferase, putative |
Trypanosoma cruzi | TcCLB.508961.20 | EMG1/NEP1 methyltransferase, putative |
Trypanosoma cruzi | TcCLB.508839.40 | EMG1/NEP1 methyltransferase, putative |
Toxoplasma gondii | TGME49_313980 | ribosome biogenesis protein nep1, putative |
Theileria parva | TP01_0556 | hypothetical protein |
Trichomonas vaginalis | TVAG_312150 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.5040 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.5040 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.5040 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.5040 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y39A1A.14 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y39A1A.14 | Caenorhabditis elegans | larval arrest | wormbase |
YLR186W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_313980 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.